Kamat Pradip P, Karaga Marie K, Wisniewski Benjamin L, McCracken Courtney E, Simon Harold K, Sidhu Reet, Grunwell Jocelyn R
1 Children's Healthcare of Atlanta at Egleston, Atlanta, GA, USA.
2 Division of Critical Care Medicine, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
J Child Neurol. 2018 Apr;33(5):313-319. doi: 10.1177/0883073817753908. Epub 2018 Feb 14.
To quantify the number of personnel, time to induce and complete sedation using propofol for outpatient magnetic resonance imaging (MRI) of the brain, and the frequency of serious adverse events (SAEs) in children with autism spectrum disorder (ASD) compared with children without ASD.
Baseline characteristics were the same between both groups. Overall sedation success was 99%. Although most children were sedated with ≤3 providers, 10% with ASD needed ≥4 providers (P = .005). The duration of sedation was less for the ASD group compared with the non-ASD group (49 minutes vs 56 minutes, P = .005). There was no difference in SAE frequency between groups (ASD 14% vs non-ASD 16%, P = .57).
Children with ASD can be sedated for brain MRI using propofol with no increased frequency of SAEs compared with children without ASD. Sedation teams should anticipate that 10% of children with ASD may need additional personnel before propofol induction.
量化使用丙泊酚对患有自闭症谱系障碍（ASD）的儿童与无ASD的儿童进行脑部门诊磁共振成像（MRI）时的人员数量、诱导和完成镇静的时间，以及严重不良事件（SAE）的发生频率。
两组的基线特征相同。总体镇静成功率为99%。尽管大多数儿童由≤3名医护人员进行镇静，但10%患有ASD的儿童需要≥4名医护人员（P = .005）。与非ASD组相比，ASD组的镇静持续时间更短（49分钟对56分钟，P = .005）。两组之间SAE发生频率无差异（ASD组为14%，非ASD组为16%，P = .57）。
与无ASD的儿童相比，使用丙泊酚对患有ASD的儿童进行脑部MRI镇静时，SAE的发生频率不会增加。镇静团队应预计到10%患有ASD的儿童在丙泊酚诱导前可能需要额外的人员。
