Division of Critical Care, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, 705 Riley Hospital Drive, Phase 2, Room 4900, Indianapolis, IN, 46202, USA.
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
J Autism Dev Disord. 2018 Sep;48(9):3127-3132. doi: 10.1007/s10803-018-3582-1.
Children with autism and autism spectrum disorders have a high incidence of neurologic comorbidities. Consequently, evaluation with magnetic resonance imaging (MRI) is deemed necessary. Sedating these patients poses several challenges. This retrospective study compared the efficacy and safety of dexmedetomidine to propofol in sedating autistic patients undergoing MRI. There were 56 patients in the dexmedetomidine group and 49 in the propofol group. All of the patients successfully completed the procedure. Recovery and discharge times were significantly lower in the propofol group, while the dexmedetomidine group maintained more stable hemodynamics. Both propofol and dexmedetomidine proved to be adequate and safe medications in the sedation of autistic children undergoing MRI.
自闭症和自闭症谱系障碍儿童的神经系统合并症发病率较高。因此，磁共振成像（MRI）评估被认为是必要的。对这些患者进行镇静存在一些挑战。这项回顾性研究比较了右美托咪定和丙泊酚在镇静自闭症患者行 MRI 中的疗效和安全性。右美托咪定组有 56 例患者，丙泊酚组有 49 例患者。所有患者均成功完成了检查。丙泊酚组的恢复和出院时间明显缩短，而右美托咪定组的血流动力学更稳定。丙泊酚和右美托咪定在镇静自闭症儿童行 MRI 中均被证明是足够和安全的药物。
