Pérez H A, Henriquez M, de la Rosa M
Mem Inst Oswaldo Cruz. 1985 Oct-Dec;80(4):429-38. doi: 10.1590/s0074-02761985000400008.
A T suppressor cell population that specifically shut down delayed hypersensitivity responses (DHR) to the parasite was found in both BALB/c mice chronically infected with Leishmania mexicana pifanoi and in naive mice which had received a single IV supraoptimal dose of killed parasites. At the early phase of infection mice exhibited a transitory state of cell-mediated immunity against the parasite that was abrogated when lesions reached their accelerated phase of growth. Results suggest that in both infected and high-dose immunized mice, the activation of T suppressor cells of DHR is related to antigen overload.
在慢性感染墨西哥利什曼原虫皮范尼株的BALB/c小鼠以及接受过一次静脉注射超最佳剂量死寄生虫的未感染小鼠中，均发现了一群特异性抑制对该寄生虫的迟发型超敏反应（DHR）的T抑制细胞。在感染早期，小鼠表现出针对该寄生虫的细胞介导免疫的短暂状态，当病变进入加速生长阶段时，这种免疫状态被消除。结果表明，在感染小鼠和高剂量免疫小鼠中，DHR的T抑制细胞的激活均与抗原过载有关。
