Li Yuyu, Zhang Jiawei, Pan Jie, Feng Xu, Duan Peipei, Yin Xing, Xu Yang, Wang Xin, Zou Shujuan
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu, 610041 China.
2Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu, 610041 China.
Cell Biosci. 2018 Feb 5;8:8. doi: 10.1186/s13578-018-0208-4. eCollection 2018.
Long noncoding RNAs (lncRNAs) are a class of non-protein-coding transcripts with the length longer than 200 nucleotides. Growing evidence suggests that lncRNAs, which were initially thought to be merely transcriptional "noise", participate in a wide repertoire of biological processes. It has been well established that lncRNAs not only play important roles in genomic regulation, transcription, posttranscriptional processes but are also implicated in the pathogenesis of human diseases including cardiovascular diseases, diabetes, neurodegenerative disorders, and cancer. However, the pathological role of lncRNAs in skeletal and dental diseases is just beginning to be uncovered. In the present review, we outline the current understanding of the established functions and underlying mechanisms of lncRNAs in various cellular processes. Furthermore, we discuss new findings on the role of lncRNAs in osteoblastogenesis and osteoclastogenesis as well as their involvement in skeletal and dental diseases. This review intends to provide a general framework for the actions of lncRNAs and highlight the emerging evidence for the functions of lncRNAs in skeletal and dental diseases.
长链非编码RNA（lncRNAs）是一类长度超过200个核苷酸的非蛋白质编码转录本。越来越多的证据表明，lncRNAs最初被认为仅仅是转录“噪音”，但它参与了广泛的生物学过程。已经明确lncRNAs不仅在基因组调控、转录、转录后过程中发挥重要作用，还与包括心血管疾病、糖尿病、神经退行性疾病和癌症在内的人类疾病的发病机制有关。然而，lncRNAs在骨骼和牙齿疾病中的病理作用才刚刚开始被揭示。在本综述中，我们概述了目前对lncRNAs在各种细胞过程中既定功能和潜在机制的理解。此外，我们讨论了lncRNAs在成骨细胞生成和破骨细胞生成中的作用以及它们在骨骼和牙齿疾病中的参与情况的新发现。本综述旨在为lncRNAs的作用提供一个总体框架，并突出lncRNAs在骨骼和牙齿疾病中功能的新出现的证据。
