Pristoupil T I, Kramlová M, Fricová V, Mosinger B
Physiol Bohemoslov. 1986;35(3):193-8.
Stroma-free solutions of human haemoglobin modified with pyridoxal-5-phosphate, glutaraldehyde, borohydride and serum albumin were injected into the artery of an isolated rat heart perfused with Krebs-Henseleit solution under hypoxic conditions. About 70% of the oxygen transported by the modified haemoglobin was found to be utilized for a marked increase in the force of heart contraction. The results were in general correlation to the analysis of oxygenation curves of haemoglobin samples under study and confirmed the oxygen offloading ability.
将用磷酸吡哆醛、戊二醛、硼氢化物和血清白蛋白修饰的人血红蛋白无基质溶液，在缺氧条件下注入用克雷布斯-亨泽莱特溶液灌注的离体大鼠心脏动脉中。发现经修饰的血红蛋白所运输的约70%的氧气被用于显著增强心脏收缩力。结果总体上与所研究的血红蛋白样品的氧合曲线分析相关，并证实了氧卸载能力。
