Haemoglobin solutions: reversibly bound oxygen and its effect upon the hypoxic heart.
作者信息
Pristoupil T I, Kramlová M, Fricová V, Mosinger B
出版信息
Physiol Bohemoslov. 1986;35(3):193-8.
PMID:2944141
Abstract
Stroma-free solutions of human haemoglobin modified with pyridoxal-5-phosphate, glutaraldehyde, borohydride and serum albumin were injected into the artery of an isolated rat heart perfused with Krebs-Henseleit solution under hypoxic conditions. About 70% of the oxygen transported by the modified haemoglobin was found to be utilized for a marked increase in the force of heart contraction. The results were in general correlation to the analysis of oxygenation curves of haemoglobin samples under study and confirmed the oxygen offloading ability.
摘要
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