Ivanov K P, Samsonov G V, Bogomolova L G, Moiseeva O I, Chuikin A E
Fiziol Zh SSSR Im I M Sechenova. 1981 Dec;67(12):1814-22.
In acute experiments on Wistar rats, after replacement of 92-94% of the blood with solution of high-molecular modified hemoglobin (HMH), 10.1-11.2 g%, the latter's oxygen transport function was studied. Prior to and after blood replacement, the gaseous composition of the blood and alveolar air, acid-alkaline condition of the blood, curves of hemoglobin dissociation, hematological parameters and survival of animals, were studied. The HMH was shown to preserve the ability to uptake and release oxygen, after administration into the vascular bed. The HMH solutions transporting the oxygen, sustain the life in rats during 9.7 +/- 2.3 hrs at a lethal degree of hemodilution (hematocrit 3.9 +/- 0.7%). Nevertheless, owing to high affinity between the HMH and oxygen and to low oxygen capacity of the solutions, the HMH is unable to maintain the initial conditions for oxygen transport to tissues.
在对Wistar大鼠进行的急性实验中，用10.1 - 11.2 g%的高分子修饰血红蛋白（HMH）溶液替代92 - 94%的血液后，对后者的氧运输功能进行了研究。在血液置换前后，研究了血液和肺泡气的气体成分、血液的酸碱状况、血红蛋白解离曲线、血液学参数以及动物的存活率。结果表明，HMH注入血管床后仍保留摄取和释放氧气的能力。在致死性血液稀释程度（血细胞比容3.9±0.7%）下，输送氧气的HMH溶液能维持大鼠生命9.7±2.3小时。然而，由于HMH与氧气之间的高亲和力以及溶液的低氧容量，HMH无法维持向组织输送氧气的初始条件。
