Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Banciao, New Taipei City, Taiwan.
Graduate Program in Biomedical Informatics, College of Informatics, Yuan-Ze University, Chung-Li, Taiwan.
Neurourol Urodyn. 2018 Jun;37(5):1773-1778. doi: 10.1002/nau.23520. Epub 2018 Feb 14.
Although asthma and bladder pain syndrome/interstitial cystitis (BPS/IC) are considered to share similar pathophysiological pathways, the relationship between asthma and BPS/IC is uncertain. This case-control study aimed to investigate the relationship between prior asthma and BPS/IC using a large database in Taiwan.
This study used data from the Taiwan Longitudinal Health Insurance Database 2005. We identified 500 female patients with BPS/IC as cases and 500 propensity score-matched females without BPS/IC as controls. We conducted logistic regressions to estimate the odds ratio (OR) and 95% confidence interval (CI) for prior asthma between cases and controls.
Results indicated that 143 (14.30%) of the total sampled patients had received a prior diagnosis of asthma. Moreover, prior asthma was found in 86 (17.20%) cases and 57 (11.40%) controls. The OR of prior asthma for cases was 1.61 (95%CI: 1.13-2.32) compared to propensity score-matched controls. Additionally, the ORs of prior asthma for females with BPS/IC aged 18-59 and ≥60 years were 1.72 (95%CI: 1.11-2.69) and 1.40 (95%CI: 0.74-2.62), respectively, compared to controls.
We concluded that prior asthma was significantly associated with BPS/IC in a female Taiwanese population.
尽管哮喘和膀胱疼痛综合征/间质性膀胱炎（BPS/IC）被认为具有相似的病理生理途径，但哮喘与 BPS/IC 之间的关系尚不确定。本病例对照研究旨在使用台湾的大型数据库来调查先前哮喘与 BPS/IC 之间的关系。
本研究使用了 2005 年台湾纵向健康保险数据库的数据。我们确定了 500 名患有 BPS/IC 的女性患者作为病例，以及 500 名具有相同倾向评分且没有 BPS/IC 的女性作为对照。我们进行了逻辑回归，以估计病例和对照组之间先前哮喘的优势比（OR）和 95％置信区间（CI）。
结果表明，总抽样患者中有 143 名（14.30％）患有先前诊断的哮喘。此外，86 例（17.20％）病例和 57 例（11.40％）对照中存在先前的哮喘。与匹配倾向评分的对照组相比，病例中先前哮喘的 OR 为 1.61（95％CI：1.13-2.32）。此外，对于年龄在 18-59 岁和≥60 岁的患有 BPS/IC 的女性，先前哮喘的 OR 分别为 1.72（95％CI：1.11-2.69）和 1.40（95％CI：0.74-2.62）。
我们得出结论，先前的哮喘与台湾女性的 BPS/IC 明显相关。
