Vrbovská H, Babincová M
Pharmazie. 2016 Dec 1;71(12):724-726. doi: 10.1691/ph.2016.6730.
Damage caused by oxidative stress in cases of neurodegenerative diseases such as Alzheimer's or Parkinson's has been proven to be irreversible. However, diet supplementation of antioxidants can be beneficial to the total antioxidant status of the human body. Given that oxidative stress is a principal cause of neurodegenerative disease, effective natural antioxidants could provide therapeutic options for these disorders. Therefore we investigated the antioxidant properties of two natural extracts and five synthetic compounds in lipid rich environment of liposomes with oxidation induced by Fenton's reagent. Antioxidant activity has been quantified using the Klein peroxidation index and oxygen uptake. Both natural extracts from Acai berry and Ginseng as well as all synthetic compounds - N-acetyl-L-cysteine, tocopherol, huperzines, caffeic acid and lipoic acid displayed good antioxidants properties, which confirm their suitability as neuroprotective agents.
在诸如阿尔茨海默病或帕金森病等神经退行性疾病中，氧化应激造成的损害已被证明是不可逆的。然而，通过饮食补充抗氧化剂对人体的总抗氧化状态可能有益。鉴于氧化应激是神经退行性疾病的主要病因，有效的天然抗氧化剂可为这些疾病提供治疗选择。因此，我们研究了两种天然提取物和五种合成化合物在由芬顿试剂诱导氧化的富含脂质的脂质体环境中的抗氧化特性。已使用克莱因过氧化指数和氧气摄取量对抗氧化活性进行了量化。来自阿萨伊浆果和人参的天然提取物以及所有合成化合物——N-乙酰-L-半胱氨酸、生育酚、石杉碱、咖啡酸和硫辛酸均表现出良好的抗氧化特性，这证实了它们作为神经保护剂的适用性。
