Laboratório de Estresse Oxidativo e Antioxidantes, Instituto de Biotecnologia, Universidade de Caxias do Sul, Caxias do Sul, Brazil.
J Med Food. 2009 Oct;12(5):1084-8. doi: 10.1089/jmf.2008.0236.
Oxidative stress is implicated in several human illnesses, including neurological disorders such as Parkinson's and Alzheimer's diseases. Acai is largely consumed in Brazil and contains high levels of antioxidant compounds. This work aims to study the antioxidant activity of acai frozen fruit pulp in the cerebral cortex, hippocampus, and cerebellum of rats treated with the oxidizing agent hydrogen peroxide (H(2)O(2)). Pretreatment of tissue with acai decreased H(2)O(2)-induced damage of both lipids and proteins in all tissues tested. This fruit was also able to reduce the activities of the antioxidant enzymes superoxide dismutase and catalase to basal levels. We observed a negative correlation between the polyphenol content of acai and the levels of lipid (r = -0.689; P <or= .05) and protein damage (r = -0.569; P <or= .05), suggesting the participation of polyphenols in the observed antioxidant activity. These data suggest that acai has a positive contribution in the development of age-related neurodegenerative diseases.
氧化应激与多种人类疾病有关，包括神经退行性疾病，如帕金森病和阿尔茨海默病。巴西人大量食用巴西莓，其含有高水平的抗氧化化合物。本研究旨在研究抗氧化剂巴西莓冷冻果浆对经氧化剂过氧化氢（H2O2）处理的大鼠大脑皮质、海马和小脑的抗氧化活性。组织预处理用巴西莓降低了所有测试组织中 H2O2 诱导的脂质和蛋白质损伤。这种水果还能够将超氧化物歧化酶和过氧化氢酶等抗氧化酶的活性降低到基础水平。我们观察到巴西莓中多酚含量与脂质（r = -0.689；P <= 0.05）和蛋白质损伤（r = -0.569；P <= 0.05）水平之间呈负相关，表明多酚参与了观察到的抗氧化活性。这些数据表明，巴西莓对与年龄相关的神经退行性疾病的发展具有积极贡献。
