A sensitive model of venous thrombosis in rats.

Several antithrombotics (heparin, acetylsalicylic acid, sulfinpyrazone and dipyridamole) as well as an antiserotonin ketanserin were tested in a new sensitive model of venous thrombosis in rats. Intravenous injection of hypotonic saline was used for thrombus induction combined with the vena cava ligation. Formation of thrombi was evaluated by their weights. With i.v. heparin, oral sulfinpyrazone and acetylsalicylic acid, i.v. dipyridamole and ketanserin an effective inhibition was obtained, whereas with oral dipyridamole and ketanserin the inhibition remained incomplete.