一种大鼠静脉血栓形成的敏感模型。

A sensitive model of venous thrombosis in rats.

作者信息

Hladovec J

出版信息

Thromb Res. 1986 Sep 1;43(5):539-44. doi: 10.1016/0049-3848(86)90073-3.

Abstract

Several antithrombotics (heparin, acetylsalicylic acid, sulfinpyrazone and dipyridamole) as well as an antiserotonin ketanserin were tested in a new sensitive model of venous thrombosis in rats. Intravenous injection of hypotonic saline was used for thrombus induction combined with the vena cava ligation. Formation of thrombi was evaluated by their weights. With i.v. heparin, oral sulfinpyrazone and acetylsalicylic acid, i.v. dipyridamole and ketanserin an effective inhibition was obtained, whereas with oral dipyridamole and ketanserin the inhibition remained incomplete.

摘要

在一种新的大鼠静脉血栓形成敏感模型中，对几种抗血栓药物（肝素、乙酰水杨酸、磺吡酮和双嘧达莫）以及一种抗5-羟色胺药物酮色林进行了测试。通过静脉注射低渗盐水并结合腔静脉结扎来诱导血栓形成。通过血栓重量评估血栓形成情况。静脉注射肝素、口服磺吡酮和乙酰水杨酸、静脉注射双嘧达莫和酮色林可有效抑制血栓形成，而口服双嘧达莫和酮色林的抑制作用仍不完全。