Shi Li, Bai Yu, Bai Yu-Long, Ma Wen, Su Juan
School of Materials Science and Engineering, Inner Mongolia University of Technology, Inner Mongolia Key Laboratory of Thin Film and Coatings, Hohhot 010051, Inner Mongolia, China.
J Nanosci Nanotechnol. 2018 Jun 1;18(6):4040-4046. doi: 10.1166/jnn.2018.15019.
Hydroxyapatite (HA) ceramics have important biomedical applications as hard tissue replacements. However, the mechanical properties and chemical stability of HA ceramics in physiological environments need to be tailored for specific applications. To improve the mechanical properties of HA ceramics, carbon nanotubes (CNTs) are introduced into HA matrix materials by an in-situ chemical synthesis method. Meanwhile, fluorine is also incorporated into the HA structure to form fluorinesubstituted hydroxyapatite (FHA). A uniform distribution of CNTs and good interfacial bonding help to improve the hardness by 76.2% and fracture toughness by 74.5% compared to pure HA. Both the dissolution behavior and antibacterial activities of CNTs/FHA composites show close relativity with the fluorine content. Increasing the fluorine contents of CNTs/FHA composites increases their chemical stability and ability to inhibit Streptococcus mutans.
羟基磷灰石（HA）陶瓷作为硬组织替代物具有重要的生物医学应用。然而，HA陶瓷在生理环境中的机械性能和化学稳定性需要针对特定应用进行调整。为了提高HA陶瓷的机械性能，通过原位化学合成方法将碳纳米管（CNT）引入HA基体材料中。同时，氟也被掺入HA结构中以形成氟取代羟基磷灰石（FHA）。与纯HA相比，碳纳米管的均匀分布和良好的界面结合有助于使硬度提高76.2%，断裂韧性提高74.5%。CNTs/FHA复合材料的溶解行为和抗菌活性均与氟含量密切相关。增加CNTs/FHA复合材料中的氟含量会提高其化学稳定性和抑制变形链球菌的能力。
