Department of Nanobiomedical Science & WCU Research Center, Dankook University Graduate School, Cheonan 330-714, Republic of Korea.
J Tissue Eng. 2011;2011:674287. doi: 10.4061/2011/674287. Epub 2011 May 25.
Hydroxyapatite (HA), as a bone mineral component, has been an attractive bioceramic for the reconstruction of hard tissues. However, its poor mechanical properties, including low fracture toughness and tensile strength, have been a significant challenge to the application of HA for the replacement of load-bearing and/or large bone defects. Among materials studied to reinforce HA, carbon nanotubes (CNTs: single-walled or multiwalled) have recently gained significant attention because of their unprecedented mechanical properties (high strength and toughness) and physicochemical properties (high surface area, electrical and thermal conductivity, and low weight). Here, we review recent studies of the organization of HA-CNTs at the nanoscale, with a particular emphasis on the functionalization of CNTs and their dispersion within an HA matrix and induction of HA mineralization. The organization of CNTs and HA implemented at the nanoscale can further be developed in the form of coatings, nanocomposites, and hybrid powders to enable potential applications in hard tissue reconstruction.
羟基磷灰石（HA）作为一种骨矿物质成分，一直是硬组织重建的一种有吸引力的生物陶瓷。然而，其机械性能较差，包括低断裂韧性和拉伸强度，这一直是 HA 作为承重和/或大骨缺损替代物应用的重大挑战。在研究用于增强 HA 的材料中，碳纳米管（CNTs：单壁或多壁）由于其前所未有的机械性能（高强度和韧性）和物理化学性能（高比表面积、导电性和导热性以及低重量）而引起了极大的关注。在这里，我们综述了最近关于 HA-CNTs 在纳米尺度上的组织的研究，特别强调了 CNTs 的功能化及其在 HA 基体中的分散以及诱导 HA 矿化。在纳米尺度上实现的 CNTs 和 HA 的组织可以进一步以涂层、纳米复合材料和混合粉末的形式进行开发，以实现硬组织重建的潜在应用。
