School of Mechanical and Electrical Engineering, Guangdong University of Petrochemical Technology, Maoming 525000, Guangdong, China.
Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan, R.O.C.
J Nanosci Nanotechnol. 2021 Jun 1;21(6):3306-3311. doi: 10.1166/jnn.2021.19074.
Magnetic nanoparticles (MNPs) subjected to external alternating magnetic field can induce heat in MNPs due to hysteresis, which is usually employed for tumor hyperthermia. An effective hyperthermia treatment should selectively kill the tumor cells without damaging the ambient healthy tissue. Hence, it is important for hyperthermia to correctly control the alternating magnetic field-induced temperature of MNPs in the tumor. This work develops a thermal model to analyze various forms of temperature-rise with time in magnetic nanoparticles for tumor hyperthermia. Results show that there are horizontal, linear rise, square root, exponential decay and abrupt temperature-rise lines with time in MNPs. The horizontal, linear rise, and square root temperature lines with time are consistent with the available experimental data. It is worthily noted that the form of abrupt temperaturerise with time can result in harm to the normal cells or tissue. If the abrupt temperature-rise does not be controlled and predicted well.
磁性纳米粒子（MNPs）在外加交变磁场的作用下会因磁滞而产生热量，这通常用于肿瘤热疗。有效的热疗应该选择性地杀死肿瘤细胞而不损伤周围的健康组织。因此，正确控制肿瘤中交变磁场诱导的 MNPs 温度对于热疗非常重要。本工作开发了一个热模型来分析肿瘤热疗中各种形式的磁纳米粒子随时间的温升。结果表明，MNPs 中存在随时间的水平、线性上升、平方根、指数衰减和急剧升温线。随时间的水平、线性上升和平方根升温线与现有的实验数据一致。值得注意的是，随时间急剧升温的形式会对正常细胞或组织造成伤害。如果不能很好地控制和预测这种急剧升温。
