Maseko Muzi, Mashao Mercy, Bawa-Allah Abdulraheem, Phukubje Edgar, Mlambo Bongubuhle, Nyundu Thamsanqa
School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Email:
School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Cardiovasc J Afr. 2018;29(3):172-176. doi: 10.5830/CVJA-2018-011. Epub 2018 Feb 12.
Previous studies conducted to investigate the relationship between sodium intake and blood pressure in our African population have yielded contradictory results. With the high prevalence of obesity in this population, it is possible that these contradictory findings are due to the masking effects of obesity on this relationship. We measured 24-hour ambulatory blood pressure and 24-hour urine excretion on 547 South Africans of African ancestry. A multivariate regression analysis revealed no independent relationship between 24-hour sodium excretion and blood pressure in the total population sample, but when participants were stratified according to body mass index (BMI) status, there was a significant association between 24-hour sodium excretion and blood pressure in the normal-BMI participants but not in the overweight/obese participants. We concluded that dietary salt intake, indexed by 24-hour urinary sodium excretion, was associated with increased ambulatory blood pressure but this relationship was masked because of a high proportion of overweight/obese individuals in this population.
此前为研究我们非洲人群中钠摄入量与血压之间的关系而开展的研究得出了相互矛盾的结果。鉴于该人群中肥胖的高患病率，这些相互矛盾的研究结果可能是由于肥胖对这种关系的掩盖作用。我们对547名非洲裔南非人测量了24小时动态血压和24小时尿排泄量。多变量回归分析显示，在总体人群样本中，24小时钠排泄量与血压之间不存在独立关系，但当根据体重指数（BMI）状态对参与者进行分层时，正常BMI参与者的24小时钠排泄量与血压之间存在显著关联，而超重/肥胖参与者则不然。我们得出结论，以24小时尿钠排泄量为指标的膳食盐摄入量与动态血压升高有关，但由于该人群中超重/肥胖个体比例较高，这种关系被掩盖了。
