1 Department of Medical Microbiology and Immunology, University of Alberta , Edmonton, Canada .
2 Department of Cell Biology, University of Alberta , Edmonton, Canada .
DNA Cell Biol. 2018 May;37(5):417-421. doi: 10.1089/dna.2018.4153. Epub 2018 Feb 14.
Peroxisomes are membrane-bound organelles that are best known for their roles in lipid metabolism. Mounting evidence indicates that they are also important nodes for antiviral signaling. While research over the past few decades has revealed effective viral strategies to block antiviral signalling pathways from the plasma membrane, mitochondria and/or the nucleus, until recently, very little was known about how viruses interfere with peroxisome-based antiviral signaling. In this essay, we review how viruses use a variety of strategies to interfere with peroxisome biogenesis, a phenomenon that has implications for evasion of the host immune system as well as pathogenesis.
过氧化物酶体是一种膜结合细胞器，其在脂质代谢中的作用最为人所知。越来越多的证据表明，它们也是抗病毒信号的重要节点。虽然过去几十年的研究揭示了有效的病毒策略，可以阻断来自质膜、线粒体和/或细胞核的抗病毒信号通路，但直到最近，人们对病毒如何干扰基于过氧化物酶体的抗病毒信号知之甚少。在本文中，我们回顾了病毒如何利用多种策略来干扰过氧化物酶体的生物发生，这一现象不仅对逃避宿主免疫系统有影响，而且对发病机制也有影响。
