Women's Reproductive Health Key Laboratory of Zhejiang Province, Women's Hospital, School of Medicine , Zhejiang University , Hangzhou 310006 , China.
MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences , Zhejiang University , Hangzhou 310058 , China.
Environ Sci Technol. 2018 Mar 6;52(5):3240-3248. doi: 10.1021/acs.est.7b06689. Epub 2018 Feb 22.
Pyrethroids are a class of widely used insecticides. Female animal studies suggested that pyrethroid exposure impaired ovarian function, which resulted in similar symptoms of primary ovarian insufficiency (POI). However, it is still unknown whether this association applies to women. In this case-control study, a total of 172 POI patients and 247 control women were recruited in Zhejiang, China. The urinary concentrations of metabolites of pyrethroids, 3-phenoxybenzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzoic acid (4-F-3-PBA), as well as the serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and anti-Mullerian hormone (AMH) were determined. The associations of pyrethroid metabolites with POI and POI-related hormones were accessed using unconditional logistic regression. Higher urinary levels of 3-PBA were significantly associated with increased risk of POI [adjusted odds ratio (OR) = 2.344, 95% CI: 1.193-4.607 for the highest vs lowest quartile of 3-PBA, p = 0.013]. Stratified analyses showed that each log increase in urinary 3-PBA concentration was significantly associated with an induction in odds of 51.0% being in the highest quartile of FSH and 28.6% being in the highest quartile of LH levels, whereas a 25.9% reduction in odds of being in the highest quartile of AMH levels (All p for trend <0.05). To our knowledge, this is the first case-control study to report an association of pyrethroid exposure with increased risk of POI in women.
拟除虫菊酯是一类广泛使用的杀虫剂。动物研究表明，接触拟除虫菊酯会损害卵巢功能，导致类似原发性卵巢功能不全（POI）的症状。然而，目前尚不清楚这种关联是否适用于女性。在这项病例对照研究中，共招募了 172 名 POI 患者和 247 名对照女性，她们来自中国浙江。测定了拟除虫菊酯代谢物 3-苯氧基苯甲酸（3-PBA）和 4-氟-3-苯氧基苯甲酸（4-F-3-PBA）的尿浓度，以及促卵泡激素（FSH）、促黄体生成素（LH）和抗苗勒管激素（AMH）的血清浓度。使用非条件逻辑回归评估了拟除虫菊酯代谢物与 POI 和与 POI 相关的激素之间的关系。较高的尿 3-PBA 水平与 POI 风险增加显著相关[最高与最低四分位数的调整比值比（OR）=2.344，95%可信区间（CI）：1.193-4.607，p=0.013]。分层分析表明，尿 3-PBA 浓度每增加一个对数，FSH 最高四分位数的可能性就会显著增加 51.0%，LH 最高四分位数的可能性会增加 28.6%，而 AMH 最高四分位数的可能性会降低 25.9%（所有趋势检验 p 值均<0.05）。据我们所知，这是第一项报告拟除虫菊酯接触与女性 POI 风险增加相关的病例对照研究。
