Jayaweera J A A S, Noordeen F, Kothalaweala S, Pitchai F N N, Rayes M L M
Department of Microbiology, Faculty of Medical and Allied Sciences, Rajarata University of Sri Lanka, Anuradhapura, Sri Lanka.
Department of Microbiology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.
BMC Res Notes. 2018 Feb 14;11(1):127. doi: 10.1186/s13104-018-3239-3.
The prevalence of hMPV infections in Sri Lanka has not been reported and here we report a case series of hMPV infection in children less than 5 years. Patients with ARTI were included from Teaching Hospital, Anuradhapura from March 2013 to August 2014. Indirect fluorescence assay was performed on nasopharyngeal aspirates for the identification of respiratory viruses [respiratory syncytial virus (RSV), parainfluenza virus 1, 2 and 3, influenza A and B and hMPV]. Moreover, reverse transcriptase-polymerase chain reaction was done to further confirm the hMPV infection.
In this case series, hMPV infection showed a range of respiratory symptoms from common cold to life threatening lower respiratory tract infections with varying severity. In some cases, the clinical presentation of hMPV infection was similar to the ARTI caused by RSV. hMPV co-infections with of RSV have also been seen in some cases of ARTI. A child delivered through cesarean section and birth order > 3 has an Odds ratio of 3.5 and 4.3 (95% CI) for developing co-infection with RSV compared to hMPV mono-infections. Lack of diagnostic facilities to identify the viral aetiology has contributed to the use of antibiotics indicating the need for establishing viral diagnostic facilities in the country.
斯里兰卡人偏肺病毒（hMPV）感染的患病率尚无报道，在此我们报告一组5岁以下儿童hMPV感染病例。2013年3月至2014年8月期间，从阿努拉德普勒教学医院纳入急性呼吸道感染（ARTI）患者。对鼻咽抽吸物进行间接荧光检测以鉴定呼吸道病毒[呼吸道合胞病毒（RSV）、副流感病毒1、2和3、甲型和乙型流感病毒以及hMPV]。此外，进行逆转录聚合酶链反应以进一步确认hMPV感染。
在该病例系列中，hMPV感染表现出一系列呼吸道症状，从普通感冒到危及生命的下呼吸道感染，严重程度各异。在某些情况下，hMPV感染的临床表现与RSV引起的ARTI相似。在一些ARTI病例中也发现了hMPV与RSV的合并感染。与hMPV单一感染相比，剖宫产分娩且出生顺序>3的儿童发生RSV合并感染的比值比为3.5和4.3（95%可信区间）。缺乏鉴定病毒病因的诊断设施导致了抗生素的使用，这表明该国需要建立病毒诊断设施。
