Fan Junsheng, Fong Tszhei, Chen Xinjie, Chen Chuyun, Luo Peng, Xie Haiting
Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Neuropsychiatr Dis Treat. 2018 Feb 9;14:495-504. doi: 10.2147/NDT.S157099. eCollection 2018.
Glia maturation factor-β (GMFB) is considered to be a growth and differentiation factor for both glia and neurons. GMFB has been found to be upregulated in several neuroinflammation and neurodegeneration conditions. It may function by mediating apoptosis and by modulating the expression of superoxide dismutase, granulocyte-macrophage colony-stimulating factor, and neurotrophin. In this review, we mainly discussed the role of GMFB in several neuroinflammatory and neurodegenerative diseases. On review of the literature, we propose that GMFB may be a promising therapeutic target for neuroinflammatory and neurodegenerative diseases.
胶质细胞成熟因子-β（GMFB）被认为是一种对胶质细胞和神经元均起作用的生长与分化因子。人们发现GMFB在多种神经炎症和神经退行性疾病中表达上调。它可能通过介导细胞凋亡以及调节超氧化物歧化酶、粒细胞-巨噬细胞集落刺激因子和神经营养因子的表达来发挥作用。在本综述中，我们主要探讨了GMFB在几种神经炎症和神经退行性疾病中的作用。通过对文献的回顾，我们提出GMFB可能是神经炎症和神经退行性疾病一个有前景的治疗靶点。
