视网膜母细胞瘤的免疫遗传学研究。
Immunogenetic studies in retinoblastoma.
作者信息
Roberts D F, Duggan-Keen M, Aherne G E, Long D R
出版信息
Br J Ophthalmol. 1986 Sep;70(9):686-91. doi: 10.1136/bjo.70.9.686.
Abstract
In three unrelated families with transmitted retinoblastoma 43 members were tested for HLA-A, B, C, and DR antigens. On 18 patients, 16 unaffected relatives, and 16 controls, mixed lymphocyte cultures were carried out and the response to mitogens, phytohaemagglutinin, concanavalin A, and pokeweed mitogen examined. There were no associations of retinoblastoma with any HLA antigen. A reduction in T cell function is suggested by the results of the mitogen tests.
摘要
在三个患遗传性视网膜母细胞瘤的非相关家庭中，对43名成员进行了HLA - A、B、C和DR抗原检测。对18名患者、16名未患病亲属和16名对照者进行了混合淋巴细胞培养，并检测了对有丝分裂原（植物血凝素、刀豆球蛋白A和商陆有丝分裂原）的反应。视网膜母细胞瘤与任何HLA抗原均无关联。有丝分裂原试验结果提示T细胞功能降低。
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Immunogenetics of retinoblastoma.视网膜母细胞瘤的免疫遗传学
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