视网膜母细胞瘤自发消退中的组织相容性分型

Histocompatibility typing in spontaneous regression of retinoblastoma.

作者信息

Gallie B L, Dupont B, Whitsett C, Kitchen F D, Ellsworth R M, Good R A

出版信息

Prog Clin Biol Res. 1977;16:229-37.

Abstract

Human Leukocyte Antigen (HLA) Typing of Caucasian patients with retinoblastoma fails to show any difference in antigen frequency compared to a control population. In family studies where several members are affected with retinoblastoma the tumor does not segregate with the HLA type. There is also no significant difference in antigen frequency between spontaneous regression of retinoblastoma, unregressed retinoblastoma, and normal controls. In several families with one member showing spontaneous regression of retinoblastoma, other generations inheriting the same haplotypes have tumors which have failed to regress.

摘要

与对照组相比，对白种人视网膜母细胞瘤患者进行人类白细胞抗原（HLA）分型，未发现抗原频率有任何差异。在一些有多名成员患视网膜母细胞瘤的家族研究中，肿瘤并不与HLA类型连锁。视网膜母细胞瘤自发消退、未消退的视网膜母细胞瘤与正常对照组之间的抗原频率也没有显著差异。在几个有一名成员视网膜母细胞瘤自发消退的家族中，继承相同单倍型的其他几代人患有未消退的肿瘤。