Nesbitt Alexander D
Sleep Disorders Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Department of Neurology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
J Thorac Dis. 2018 Jan;10(Suppl 1):S103-S111. doi: 10.21037/jtd.2018.01.11.
Delayed sleep-wake phase disorder (DSWPD) is the most commonly encountered of the circadian rhythm sleep-wake disorders (CRSDs), and is often confused with sleep initiation insomnia. It typically emerges in teenage years and persists into adulthood. In essence, people with the disorder have an abnormally delayed major sleep episode relative to the dark phase of the solar cycle, and hence great difficulty initiating sleep at an appropriately early time, and, as a knock-on effect, waking at a desirable time in the morning, leading to chronic, and often quite severe sleep restriction trying to conform to a 9 to 5 schedule. As a result, sleep on free days is often extended in compensation. When released from such schedule constraints, sleep duration and quality is normal; it is just delayed. This review highlights elements of our current understanding of the epidemiology, associations and pathophysiology of the disorder, before discussing how some of our knowledge of sleep and circadian physiology can be applied to guide treatment of it.
延迟睡眠-觉醒相位障碍(DSWPD)是昼夜节律性睡眠-觉醒障碍(CRSDs)中最常见的一种,常与入睡性失眠相混淆。它通常在青少年时期出现,并持续到成年期。本质上,患有这种障碍的人相对于太阳周期的黑暗阶段,主要睡眠时段异常延迟,因此在适当早的时间入睡非常困难,并且,作为一种连锁反应,在早上期望的时间醒来也很困难,导致试图遵循朝九晚五的时间表时出现慢性且往往相当严重的睡眠限制。结果,在休息日睡眠常常会延长以作补偿。当从这种时间表限制中解脱出来时,睡眠时间和质量是正常的,只是延迟了。在讨论如何将我们对睡眠和昼夜生理的一些知识应用于指导其治疗之前,本综述重点介绍了我们目前对该障碍的流行病学、关联因素和病理生理学的理解要点。