胰岛素水平与非精神病性痴呆的关系：系统评价和荟萃分析。
Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis.
机构信息
School of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, China.
出版信息
Neural Plast. 2017;2017:1230713. doi: 10.1155/2017/1230713. Epub 2017 Dec 27.
OBJECTIVES
To explore the relationship between insulin levels and nonpsychotic dementia.
METHODS
Six electronic databases (PubMed, Cochrane, SCI, CNKI, VIP, and Wanfang) were searched from January 1, 2007, to March 1, 2017. Experimental or observational studies that enrolled people with nonpsychotic dementia or abnormal insulin levels in which insulin levels or MMSE scores (events in nonpsychotic dementia) were the outcome measures. Random-effects models were chosen for this meta-analysis. Sample size, mean, s.d., and events were primarily used to generate effect sizes (with the PRIMA registration number CRD42017069860).
RESULTS
50 articles met the final inclusion criteria. Insulin levels in cerebrospinal fluid were lower (Hedges' = 1.196, 95% CI = 0.238 to 2.514, and = 0.014), while the levels in peripheral blood were higher in nonpsychotic dementia patients (Hedges' = 0.853 and 95% CI = 0.579 to 1.127), and MMSE scores were significantly lower in the high insulin group than in the healthy control group (Hedges' = 0.334, 95% CI = 0.249 to 0.419, and = 0.000).
CONCLUSIONS
Our comprehensive results indicate that blood insulin levels may increase in patients with nonpsychotic dementia.
目的
探讨胰岛素水平与非精神病性痴呆的关系。
方法
检索 2007 年 1 月 1 日至 2017 年 3 月 1 日的 6 个电子数据库（PubMed、Cochrane、SCI、CNKI、VIP 和万方），纳入评估非精神病性痴呆或胰岛素水平异常患者的实验或观察性研究，以胰岛素水平或 MMSE 评分（非精神病性痴呆的结局指标）作为观察结果。采用随机效应模型进行荟萃分析。主要使用样本量、均数、标准差和事件来计算效应量（PRIMA 注册号 CRD42017069860）。
结果
最终纳入 50 篇文献。非精神病性痴呆患者脑脊液中的胰岛素水平较低（Hedges' = 1.196，95%CI = 0.238 至 2.514， = 0.014），而外周血中的胰岛素水平较高（Hedges' = 0.853，95%CI = 0.579 至 1.127），高胰岛素组的 MMSE 评分明显低于健康对照组（Hedges' = 0.334，95%CI = 0.249 至 0.419， = 0.000）。
结论
综合结果表明，非精神病性痴呆患者的血液胰岛素水平可能升高。
Zotero 插件