Sultan Faheem, Ganaie Bilal Ahmad
Indian Council of Medical Research, GADVASU-Ludhiana Punjab-141004, India.
National Dairy Research Institute, Karnal Haryana-132001, India.
Open Vet J. 2018;8(1):25-34. doi: 10.4314/ovj.v8i1.5. Epub 2018 Jan 30.
Cancer constitutes the major health problem both in human and veterinary medicine. Comparative oncology as an integrative approach offers to learn more about naturally occurring cancers across different species. Canine models have many advantages as they experience spontaneous disease, have many genes similar to human genes, five to seven-fold accelerated ageing compared to humans, respond to treatments similarly as humans do and health care levels second only to humans. Also, the clinical trials in canines could generate more robust data, as their spontaneous nature mimics real-life situations and could be translated to humans.
癌症是人类医学和兽医学中的主要健康问题。比较肿瘤学作为一种综合方法,有助于更多地了解不同物种中自然发生的癌症。犬类模型具有许多优势,因为它们会患自发性疾病,拥有许多与人类基因相似的基因,与人类相比衰老速度快五到七倍,对治疗的反应与人类相似,并且医疗保健水平仅次于人类。此外,犬类的临床试验可以产生更可靠的数据,因为它们的自发性本质模拟了现实生活情况,并且可以应用于人类。