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骨髓干细胞用于清除循环中的HIV:一种假设的治疗策略。

Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy.

作者信息

Halder Umesh Chandra

机构信息

Department of Zoology, Raniganj Girls' College, Searsole, Rajbari, Raniganj, Paschim Barddhaman, West Bengal 713358 India.

出版信息

J Biol Res (Thessalon). 2018 Feb 5;25:3. doi: 10.1186/s40709-018-0075-5. eCollection 2018 Dec.

Abstract

Human immunodeficiency virus (HIV) still poses enigmatic threats to human life. This virus has mastered in bypassing anti retroviral therapy leading to patients' death. Circulating viruses are phenomenal for the disease outcome. This hypothesis proposes a therapeutic strategy utilizing receptor-integrated hematopoietic, erythroid and red blood cells. Here, HIV specific receptors trap circulating viruses that enter erythrocyte cytoplasm and form inactive integration complex. This model depicts easy, effective removal of circulating HIV without any adverse effect.

摘要

人类免疫缺陷病毒(HIV)仍然对人类生命构成神秘威胁。这种病毒已掌握了绕过抗逆转录病毒疗法的方法,导致患者死亡。循环病毒对疾病结果至关重要。该假说提出了一种利用受体整合的造血细胞、红细胞和红细胞的治疗策略。在这里,HIV特异性受体捕获进入红细胞细胞质并形成无活性整合复合物的循环病毒。该模型描述了轻松、有效地清除循环HIV且无任何不良影响的过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3f4/5800069/18b6db3cdeee/40709_2018_75_Fig1_HTML.jpg

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