Chemical Engineering and Statistics Department, Federal University of São João Del Rei, São João Del Rei, MG, Brazil.
Department of Civil and Environmental Engineering, University of Texas at San Antonio, UTSA, San Antonio, TX, 78249, USA.
Environ Monit Assess. 2018 Feb 14;190(3):140. doi: 10.1007/s10661-018-6523-8.
Amoxicillin is a useful antibiotic to combat bacterial infections. However, this drug can cause serious problems when discarded in waterways due to its great bioaccumulation potential. This compound can be treated via advanced oxidation processes (AOPs), which are capable of converting amoxicillin into carbon dioxide and water. In this context, the use of ozone as an oxidizer has excelled in amoxicillin degradation. This paper aims at treating a synthetic solution of amoxicillin (0.1 g L) in a reactor with ozone bubbling. A Design of Experiment (DoE) with a response surface known as Central Composite Design (CCD) was used to optimize the treatment process. In addition, a Normal Boundary Intersection (NBI) method was used in the construction of a Pareto boundary chart. Results after 1-h treatment showed a reduction of 53% of the initial organic matter from a designed model using factors, such as pH, ozone generator power, and O flow. A model was built from the CCD with score of 0.9929. Thus, the model was able to represent the real scenario with confidence.
阿莫西林是一种用于对抗细菌感染的有用抗生素。然而，由于其具有很强的生物累积潜力，当这种药物被丢弃在水道中时，会导致严重的问题。该化合物可以通过高级氧化工艺（AOPs）进行处理，该工艺能够将阿莫西林转化为二氧化碳和水。在这种情况下，臭氧作为氧化剂在阿莫西林的降解方面表现出色。本文旨在使用臭氧鼓泡的反应器处理阿莫西林（0.1 g/L）的合成溶液。使用响应面设计的实验设计（DoE），即中心复合设计（CCD），来优化处理过程。此外，还使用正常边界交集（NBI）方法构建了 Pareto 边界图。在 1 小时的处理后，结果显示初始有机物减少了 53%，这是使用 pH、臭氧发生器功率和 O 流等因素设计模型的结果。通过 CCD 构建了一个得分 0.9929 的模型。因此，该模型能够自信地代表真实情况。
