LEPÆ, Departamento de Engenharia Química, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
Sci Total Environ. 2010 Nov 15;408(24):6272-80. doi: 10.1016/j.scitotenv.2010.08.058. Epub 2010 Sep 27.
A central composite factorial design methodology was employed to optimise the amoxicillin degradation using the Fenton's oxidation treatment. In this study, the variables considered for the process optimisation were the hydrogen peroxide and ferrous ion initial concentrations and the temperature, for an antibiotic concentration of 450μg L(-1) at pH=3.5. This methodology also allowed assessing and identifying the effects of the different factors studied and their interactions in the process response. An appropriate quadratic model was developed in order to plot the response surface and contour curves, which was used to perform the process optimisation. From this study, it was concluded that ferrous ion concentration and temperature were the variables that most influenced the response. Under the optimal conditions (hydrogen peroxide concentration=3.50-4.28mg L(-1), ferrous ion concentration=254-350μg L(-1) and temperature=20-30°C), it was possible to achieve total amoxicillin degradation after 30min of reaction.
采用中心复合因子设计方法，通过芬顿氧化处理对阿莫西林的降解进行优化。在这项研究中，考虑了变量的初始浓度和温度的过氧化氢和亚铁离子，抗生素浓度为 450μg L(-1)，pH 值=3.5。该方法还可以评估和识别不同因素的影响及其在过程响应中的相互作用。为了绘制响应面和等高线曲线，开发了一个合适的二次模型，用于进行过程优化。从这项研究中得出的结论是，亚铁离子浓度和温度是对响应影响最大的两个变量。在最佳条件下（过氧化氢浓度=3.50-4.28mg L(-1)，亚铁离子浓度=254-350μg L(-1)和温度=20-30°C），反应 30 分钟后可以实现阿莫西林的完全降解。
