School of Paediatrics and Child Health, University of Western Australia , Perth, Australia .
Viral Immunol. 2018 May;31(4):299-305. doi: 10.1089/vim.2017.0152. Epub 2018 Feb 15.
To assess if the difference in species-specific immune response to RV-C correlates with a higher frequency of reinfection, shorter time to reinfection, or different symptom severity than infections with RV-A or RV-B. Forty-three patients were enrolled of which 34 were successfully tracked longitudinally over 3 months, with nasal swabs and symptom questionnaires provided every 2 weeks to identify rhinovirus (RV) strains and the concurrent symptomatology. No difference was found in the time to reinfection with an RV species between RV-C and RV-A or RV-B (p = 0.866). There was a trend toward more rapid reinfection with the same species in RV-C than RV-A (55.1 days vs. 67.9 days), but this failed to reach statistical significance (p = 0.105). RV infections were generally associated with only minor symptoms, with rhinorrhea being the only significantly associated symptom (p = 0.01). RV-C was shown to have higher levels of lethargy and wheeze than other RV species. Time to reinfection with subsequent RV is not influenced by the species of the preceding RV.
为了评估 RV-C 特异性免疫反应的差异是否与更高的再感染频率、更短的再感染时间或与 RV-A 或 RV-B 感染相比不同的症状严重程度相关。共纳入 43 名患者，其中 34 名患者成功进行了 3 个月的纵向随访，每 2 周提供鼻拭子和症状问卷，以确定鼻病毒 (RV) 株和同时出现的症状。在 RV-C 与 RV-A 或 RV-B 之间，再感染 RV 种的时间没有差异（p=0.866）。与 RV-A 相比，RV-C 中同种 RV 的再感染有更快的趋势（55.1 天对 67.9 天），但未达到统计学意义（p=0.105）。RV 感染通常与仅轻微的症状相关，其中流鼻涕是唯一具有显著相关性的症状（p=0.01）。与其他 RV 种相比，RV-C 表现出更高的嗜睡和喘息水平。随后 RV 的再感染时间不受先前 RV 种的影响。
