Hatem Shymaa, Nasr Maha, Elkheshen Seham A, Geneidi Ahmed S
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, New Cairo, Egypt.
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Curr Drug Deliv. 2018;15(7):953-964. doi: 10.2174/1567201815666180214143551.
Antioxidants are among the most important cosmeceuticals, with proven ability of inhibiting cellular damage. The topical skin administration of antioxidants is essential for minimizing skin aging and achieving better skin protection against harmful free radicals. However, their unfavorable physiochemical properties such as chemical instability, excessive hydrophilicity or lipophilicity and others could be a great obstacle against their skin promising effects as well as their delivery to deeper skin layers. These problems could all be remedied through the use of delivery carriers. The present review discusses the various delivery carriers which were proven successful in improving the beneficial effects of antioxidants against skin aging, namely different vesicular systems, lipidic systems, polymeric systems and carbon nanotubes, and their applications in topical antioxidant delivery.
抗氧化剂是最重要的药妆品之一，具有已被证实的抑制细胞损伤的能力。局部皮肤施用抗氧化剂对于将皮肤老化降至最低以及实现更好的皮肤免受有害自由基的保护至关重要。然而，它们不利的物理化学性质，如化学不稳定性、过度的亲水性或亲脂性等，可能成为阻碍其发挥皮肤预期效果以及输送到皮肤深层的巨大障碍。这些问题都可以通过使用递送载体来补救。本综述讨论了各种已被证明成功改善抗氧化剂抗皮肤老化有益效果的递送载体，即不同的囊泡系统、脂质系统、聚合物系统和碳纳米管，以及它们在局部抗氧化剂递送中的应用。
