McLean K E, Stone J
a Centre for Genetic Origins of Health and Disease , Curtin University and The University of Western Australia , Perth , WA , Australia.
Climacteric. 2018 Jun;21(3):214-220. doi: 10.1080/13697137.2018.1424816. Epub 2018 Feb 15.
Mammographic breast density is an established risk factor for breast cancer and significantly reduces the sensitivity of mammography, yet its use within breast cancer screening programs in Australia is limited. We provide a contemporary snapshot of the role of breast density measurement in screening for breast cancer and review the recent evidence for an increasing role of breast density measurement as: a predictor of breast cancer risk, a predictor of 'masking', and a biomarker to monitor effectiveness of intervention strategies for primary prevention or improved breast cancer outcomes.
乳腺钼靶密度是乳腺癌已确定的风险因素，且会显著降低钼靶检查的敏感性，但在澳大利亚的乳腺癌筛查项目中其应用有限。我们提供了乳腺密度测量在乳腺癌筛查中作用的当代概况，并回顾了近期证据，表明乳腺密度测量在以下方面的作用日益增加：作为乳腺癌风险的预测指标、“掩盖”现象的预测指标，以及监测一级预防干预策略有效性或改善乳腺癌结局的生物标志物。
