Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Kiel, Germany.
Pain. 2018 Mar;159(3):569-575. doi: 10.1097/j.pain.0000000000001088.
Patients with the same neuropathic pain disorder may have completely different sensory signs and symptoms yet receive the same medicinal treatment. New concepts suggest that patient stratification according to their pain mechanisms, reflected in their sensory phenotype, could be promising to implement an individualized therapy in neuropathic pain. Retrospective classification of patients according to their sensory phenotype showed predictive validity and reliability for treatment response in certain subgroups of patients. Recent prospective studies using stratification based on sensory phenotypes confirm this concept. In this article, we review the recent accomplishments towards an individualized pharmacological treatment of neuropathic pain.
患有相同神经病理性疼痛障碍的患者可能具有完全不同的感觉体征和症状，但却接受相同的药物治疗。新概念表明，根据疼痛机制对患者进行分层，反映在他们的感觉表型上，可能有望在神经病理性疼痛中实施个体化治疗。根据感觉表型对患者进行回顾性分类显示出对某些亚组患者治疗反应的预测性和可靠性。最近使用基于感觉表型的分层进行的前瞻性研究证实了这一概念。在本文中，我们回顾了在实现神经病理性疼痛的个体化药物治疗方面的最新成果。
