Forstenpointner Julia, Rehm Stefanie, Gierthmühlen Janne, Baron Ralf
Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Curr Opin Anaesthesiol. 2018 Oct;31(5):562-568. doi: 10.1097/ACO.0000000000000642.
It has been demonstrated that within one pain entity, patients may report highly heterogenic sensory signs and symptoms. Although mechanism might differ fundamentally between those patients, yet the treatment recommendations are uniform throughout all phenotypes. Therefore, the introduction of new stratification tools could pave the way to an individualized pain treatment.
In the past, retrospective stratifications of patients successfully identified responders to certain pharmacological treatments. This indicated predictive validity and reliability of this classification tool in those patient subgroups. Further on, these observations have been confirmed in prospective studies.
This review focusses on recent achievements in neuropathic pain and suggests a promising implementation of an individualized pharmacological therapy in the future.
已证实，在一种疼痛类型中，患者可能报告高度异质性的感觉体征和症状。尽管这些患者之间的机制可能存在根本差异，但所有表型的治疗建议都是统一的。因此，引入新的分层工具可能为个体化疼痛治疗铺平道路。
过去，对患者进行的回顾性分层成功识别出了对某些药物治疗有反应者。这表明该分类工具在这些患者亚组中具有预测有效性和可靠性。此外，这些观察结果在前瞻性研究中得到了证实。
本综述重点关注神经病理性疼痛的最新进展，并提出了未来个体化药物治疗的一个有前景的实施方案。
