[雄甾烷激素非活性衍生物的精神活性特性]
[Psychotropic properties of hormonally inactive derivatives of androstane].
作者信息
Burov Iu V, Vedernikova N N, Orekhov S N, Klimova L I
出版信息
Farmakol Toksikol. 1986 Jan-Feb;49(1):23-6.
It has been shown in experiments on noninbred male rats that 17 beta-acetylamino-5-androstene-3 beta,16 beta-diol, 17 beta-amino-5-androstene-3 beta,16 beta-diol hydrochloride, and 17 beta-acetylamino-4-androstene-3,16-dione have an anxiolytic action. These compounds do not exhibit any myorelaxant, anticonvulsant or antineurotic activity common to benzodiazepine tranquilizers. The anxiolytic effect of the compounds under consideration is coupled with the ability to reduce the level of alcoholic motivation in rats.
在非近交雄性大鼠身上进行的实验表明，17β-乙酰氨基-5-雄烯-3β,16β-二醇、17β-氨基-5-雄烯-3β,16β-二醇盐酸盐以及17β-乙酰氨基-4-雄烯-3,16-二酮具有抗焦虑作用。这些化合物不表现出苯二氮䓬类镇静剂常见的任何肌松、抗惊厥或抗神经症活性。所研究化合物的抗焦虑作用与降低大鼠酒精动机水平的能力相关。
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