Transfusion Medicine Department, University Hospital of Larisa, Biopolis, 41334 Larisa, Greece.
Med Hypotheses. 2018 Mar;112:47-50. doi: 10.1016/j.mehy.2018.01.011. Epub 2018 Jan 31.
Human Herpes Virus type 6 (HHV-6) is a ubiquitous virus consisting of two viral species, HHV-6A and HHV-6B that have been associated with numerous and diverse pathologies. As many other viruses HHV-6 modulates the apoptotic machinery of its host to subvert immune response to infection, yet the exact mechanisms behind this process remain under investigation. The genes encoding the CTSS, PTX3, CHI3L1, Mx1, CXCL16, BIRC3 and BST2 proteins have been linked to HHV-6Α related neurologic diseases whilst also associated with apoptosis. This study aimed at the identification and functional analysis of the gene interaction network (interactome) of CTSS-PTX3-CHI3L1-Mx1-CXCL16-BIRC3-BST2 so as to evaluate the hypothesis of a probable link between the latter and host's immune response to HHV-6A infection.
人类疱疹病毒 6 型（HHV-6）是一种普遍存在的病毒，由两种病毒株组成，即 HHV-6A 和 HHV-6B，它们与许多不同的病理学有关。与许多其他病毒一样，HHV-6 调节宿主的细胞凋亡机制，以颠覆对感染的免疫反应，但这一过程的确切机制仍在研究中。编码 CTSS、PTX3、CHI3L1、Mx1、CXCL16、BIRC3 和 BST2 蛋白的基因与 HHV-6Α 相关的神经疾病有关，同时也与细胞凋亡有关。本研究旨在鉴定和分析 CTSS-PTX3-CHI3L1-Mx1-CXCL16-BIRC3-BST2 基因相互作用网络（相互作用组），以评估它们与宿主对 HHV-6A 感染的免疫反应之间可能存在联系的假设。
