J Nat Prod. 2020 Feb 28;83(2):216-222. doi: 10.1021/acs.jnatprod.9b00470. Epub 2020 Jan 29.
Palhinosides A-H (-), new flavone glucosidic truxinate esters, including β-truxinate and μ-truxinate forms, were isolated from . Their structures were elucidated by extensive spectroscopic methods and chemical analyses. The flavone glucoside cyclodimers possess a unique cyclobutane ring in their carbon scaffolds. Compounds - represent three pairs of stereoisomers (, , ). The protective effects of - against the damage of HT-22 cells induced by l-glutamate were evaluated, and compounds and showed better neuroprotective effects than the positive control, Trolox.
Palhinosides A-H(-)，包括β-和μ-形式的新黄酮葡萄糖基曲辛酯，从 中分离得到。通过广泛的光谱方法和化学分析阐明了它们的结构。黄酮葡萄糖苷环二聚体在其碳骨架中具有独特的环丁烷环。化合物 - 代表三对对映异构体（，，）。评估了 - 对 l-谷氨酸诱导的 HT-22 细胞损伤的保护作用，化合物 和 显示出比阳性对照 Trolox 更好的神经保护作用。
