Palhinosides A-H: Flavone Glucosidic Truxinate Esters with Neuroprotective Activities from .

Palhinosides A-H (-), new flavone glucosidic truxinate esters, including β-truxinate and μ-truxinate forms, were isolated from . Their structures were elucidated by extensive spectroscopic methods and chemical analyses. The flavone glucoside cyclodimers possess a unique cyclobutane ring in their carbon scaffolds. Compounds - represent three pairs of stereoisomers (, , ). The protective effects of - against the damage of HT-22 cells induced by l-glutamate were evaluated, and compounds and showed better neuroprotective effects than the positive control, Trolox.