从壮观链霉菌BCC 4785中分离出的间环丙基灵菌红素具有强大的体外抗疟活性。
Potent in vitro antimalarial activity of metacycloprodigiosin isolated from Streptomyces spectabilis BCC 4785.
作者信息
Isaka Masahiko, Jaturapat Amonlaya, Kramyu Jarin, Tanticharoen Morakot, Thebtaranonth Yodhathai
机构信息
National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Bangkok 10400, Thailand.
出版信息
Antimicrob Agents Chemother. 2002 Apr;46(4):1112-3. doi: 10.1128/AAC.46.4.1112-1113.2002.
Abstract
Bioassay-guided fractionation of the extract from the fermentation broth of Streptomyces spectabilis BCC 4785 led to the isolation of three principle antimalarial agents, metacycloprodigiosin, bafilomycin A(1), and spectinabilin. Metacycloprodigiosin exhibited potent in vitro activity against Plasmodium falciparum K1, with a 50% inhibitory concentration of 0.0050 +/- 0.0010 microg/ml, while its cytotoxicity was much weaker.
摘要
对壮观链霉菌BCC 4785发酵液提取物进行生物测定导向的分级分离，得到了三种主要抗疟剂，即间环丙基灵菌红素、巴弗洛霉素A(1)和壮观菌素。间环丙基灵菌红素对恶性疟原虫K1表现出强大的体外活性，50%抑制浓度为0.0050±0.0010微克/毫升，而其细胞毒性则弱得多。
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