Chambers James K, Shiga Takanori, Takimoto Haruka, Dohata Atsushi, Miwa Yasutsugu, Nakayama Hiroyuki, Uchida Kazuyuki
1 Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan.
2 Miwa Exotic Animal Hospital, Tokyo, Japan.
Vet Pathol. 2018 Jul;55(4):562-571. doi: 10.1177/0300985818758467. Epub 2018 Feb 15.
Uteri from 50 four-toed hedgehogs ( Atelerix albiventris) with clinical signs of uterine disease were histopathologically examined. Sixteen animals (32%) were diagnosed with endometrial hyperplasia, 7 animals (14%) were diagnosed with endometrial polyp, and 27 animals (54%) were diagnosed with endometrial neoplasia. The mean ages of the animals with endometrial hyperplasia, polyp, and neoplasia were 28.7 months, 29.4 months, and 25.2 months, respectively. The neoplasms were classified into 7 endometrial mixed tumors, 12 endometrial stromal nodules, and 8 endometrial stromal sarcomas. However, the endometrial stromal nodules and endometrial stromal sarcomas often developed within or were contiguous with an endometrial polyp or mixed tumor. Interestingly, the stromal tumors and the stromal components of the endometrial polyp and mixed tumor displayed extraendometrial differentiation (eg, into adipocytes, granular cells, smooth muscle cells, and osteoid tissue). The endometrial stromal sarcomas exhibited severe cellular atypia and invaded subendometrial tissue. Immunohistochemical examinations demonstrated that the stromal cells of the hyperplastic lesions as well as the neoplastic lesions were positive for CD10, the progesterone receptor, and Wilms tumor 1. The four-toed hedgehog develops unique uterine neoplasms that are mainly composed of endometrial stromal cells and probably arise from endometrial polyps and/or mixed tumors.
对50只出现子宫疾病临床症状的四趾刺猬（Atelerix albiventris）的子宫进行了组织病理学检查。16只动物（32%）被诊断为子宫内膜增生，7只动物（14%）被诊断为子宫内膜息肉，27只动物（54%）被诊断为子宫内膜肿瘤。患有子宫内膜增生、息肉和肿瘤的动物的平均年龄分别为28.7个月、29.4个月和25.2个月。这些肿瘤分为7例子宫内膜混合瘤、12例子宫内膜间质结节和8例子宫内膜间质肉瘤。然而，子宫内膜间质结节和子宫内膜间质肉瘤常发生于子宫内膜息肉或混合瘤内或与之相邻。有趣的是，间质肿瘤以及子宫内膜息肉和混合瘤的间质成分表现出子宫内膜外分化（如分化为脂肪细胞、颗粒细胞、平滑肌细胞和类骨组织）。子宫内膜间质肉瘤表现出严重的细胞异型性并侵犯子宫内膜下组织。免疫组织化学检查显示，增生性病变以及肿瘤性病变的间质细胞CD10、孕激素受体和肾母细胞瘤1均呈阳性。四趾刺猬会发生独特的子宫肿瘤，主要由子宫内膜间质细胞组成，可能起源于子宫内膜息肉和/或混合瘤。
