Wu Chih Chun, Nakata Makoto, Chambers James Kenn, Uchida Kazuyuki, Sasaki Nobuo, Miwa Yasutsugu
Miwa Exotic Animal Hospital, 1-25-5 Komagome, Toshima-ku, Tokyo170-0003, Japan.
Vision Vets Group Lab, #201 Naeshiro Bldg., 1-24-6 Komagome, Toshima-ku, Tokyo 170-0003, Japan.
J Vet Med Sci. 2021 Apr 9;83(4):685-688. doi: 10.1292/jvms.20-0521. Epub 2021 Feb 17.
A retrospective study involving eight African pygmy hedgehogs histopathologically diagnosed with granulosa cell tumors was conducted. The age at onset was 2.2-4.5 years, with a median age of 3.6 years. The most common clinical signs were hematuria and abdominal distension, which were observed in >50% cases. Exploratory laparotomy was performed in all cases, and ovariohysterectomy or excision of the abdominal mass was performed. Patients with only hematuria survived for >250 days after surgery, whereas those with initial ascites showed recurrence of ascites or tumor growth and survived for approximately 130 days after surgery. Intraperitoneal injection of carboplatin was performed in three recurrent cases. In one of these three cases, the tumor mass disappeared. Hence, carboplatin can be considered a potential antineoplastic drug for the treatment of granulosa cell tumors.
开展了一项回顾性研究，涉及8只经组织病理学诊断患有颗粒细胞瘤的非洲侏儒刺猬。发病年龄为2.2至4.5岁，中位年龄为3.6岁。最常见的临床症状是血尿和腹胀，超过50%的病例出现这些症状。所有病例均进行了剖腹探查，并实施了卵巢子宫切除术或腹部肿块切除术。仅出现血尿的患者术后存活超过250天，而最初出现腹水的患者则出现腹水复发或肿瘤生长，术后存活约130天。3例复发病例进行了腹腔注射卡铂治疗。在这3例病例中的1例中，肿瘤肿块消失。因此，卡铂可被视为治疗颗粒细胞瘤的一种潜在抗肿瘤药物。
