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分析在接种猪繁殖与呼吸综合征病毒疫苗的猪中，在攻毒后出现短暂或长期病毒血症的猪的遗传多样性和 mRNA 表达水平。

Analysis of the genetic diversity and mRNA expression level in porcine reproductive and respiratory syndrome virus vaccinated pigs that developed short or long viremias after challenge.

机构信息

Departament de Sanitat i d'Anatomia Animals, Universitat Autònoma de Barcelona, 08193, Cerdanyola Del Vallès, Spain.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, EH25 9RG, UK.

出版信息

Vet Res. 2018 Feb 15;49(1):19. doi: 10.1186/s13567-018-0514-1.

DOI:10.1186/s13567-018-0514-1
PMID:29448955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5815215/
Abstract

Porcine reproductive and respiratory syndrome virus (PRRSv) infection alters the host's cellular and humoral immune response. Immunity against PRRSv is multigenic and vary between individuals. The aim of the present study was to compare several genes that encode for molecules involved in the immune response between two groups of vaccinated pigs that experienced short or long viremic periods after PRRSv challenge. These analyses include the sequencing of four SLA Class I, two Class II allele groups, and CD163, plus the analysis by quantitative realtime qRT-PCR of the constitutive expression of TLR2, TLR3, TLR4, TLR7, TLR8 and TLR9 mRNA and other molecules in peripheral blood mononuclear cells.

摘要

猪繁殖与呼吸综合征病毒（PRRSv）感染会改变宿主的细胞和体液免疫反应。针对 PRRSv 的免疫是多基因的，并且在个体之间存在差异。本研究的目的是比较两组接种疫苗的猪在 PRRSv 攻毒后经历短暂或长期病毒血症期间，参与免疫反应的几种基因。这些分析包括对四个 SLA 类 I、两个类 II 等位基因群和 CD163 进行测序，以及定量实时 qRT-PCR 分析外周血单个核细胞中 TLR2、TLR3、TLR4、TLR7、TLR8 和 TLR9 mRNA 及其他分子的组成型表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8f/5815215/2ade25be84ce/13567_2018_514_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8f/5815215/5e9b29f9a433/13567_2018_514_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8f/5815215/2ade25be84ce/13567_2018_514_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8f/5815215/5e9b29f9a433/13567_2018_514_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f8f/5815215/2ade25be84ce/13567_2018_514_Fig2_HTML.jpg

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本文引用的文献

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J Gen Virol. 2017 Aug;98(8):2030-2042. doi: 10.1099/jgv.0.000859. Epub 2017 Jul 26.
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Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus.猪繁殖与呼吸综合征病毒适应性免疫机制
Viruses. 2017 Jun 13;9(6):148. doi: 10.3390/v9060148.
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Cost of porcine reproductive and respiratory syndrome virus at individual farm level - An economic disease model.
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