Khalele B Ae O
Department of Diagnostic Pathology, Ministry of Health, Egypt.
Pathologica. 2017 Dec;109(4):379-381.
Adenomatoid odontogenic tumor (AOT) is always benign. Given the very rare recurrence rate and the zero potential of malignant transformation, authors have considered it a hamartoma. Accordingly, 'AOT' is no more than a misnomer. This report, however, describes the first recognition of cellular atypia and plemorphism in a peripheral orophayrngeal AOT which embraces an ameloblastic component. The overall picture was diagnosed, after careful histological and immunohitochemical assessment, as a peripheral adenoid ameloblastoma. This find may promote a new pathogenetic scenario to the nosology of this debatable lesion.
腺牙源性肿瘤（AOT）通常为良性。鉴于其极低的复发率和零恶变潜能，作者们曾认为它是一种错构瘤。因此，“AOT”不过是一个误称。然而，本报告描述了首例在外周口咽AOT中识别出细胞异型性和多形性，该AOT包含成釉细胞成分。经过仔细的组织学和免疫组织化学评估后，整体诊断为外周腺样成釉细胞瘤。这一发现可能会为这种有争议病变的分类学带来新的发病机制设想。
