O'Hare Justin, Calakos Nicole, Yin Henry H
Department of Neurobiology, Duke University.
Department of Neurology, Duke University.
Curr Opin Behav Sci. 2018 Apr;20:40-46. doi: 10.1016/j.cobeha.2017.10.001. Epub 2017 Oct 27.
Habits have been studied for decades, but it was not until recent years that experiments began to elucidate the underlying cellular and circuit mechanisms. The latest experiments have been enabled by advances in cell-type specific monitoring and manipulation of activity in large neuronal populations. Here we will review recent efforts to understand the neural substrates underlying habit formation, focusing on rodent studies on corticostriatal circuits.
习惯已经被研究了几十年,但直到近年来,实验才开始阐明其潜在的细胞和神经回路机制。细胞类型特异性监测和对大量神经元群体活动的操纵技术的进步,使得最新的实验得以开展。在这里,我们将回顾最近在理解习惯形成背后的神经基础方面所做的努力,重点关注啮齿动物的皮质纹状体回路研究。