尿酸水平与肾功能快速下降及肾脏病发生的关系：杰克逊心脏研究。
Relation of uric acid level to rapid kidney function decline and development of kidney disease: The Jackson Heart Study.
机构信息
Jackson Heart Study, Jackson State University, Jackson, MS, USA.
Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC, USA.
出版信息
J Clin Hypertens (Greenwich). 2018 Apr;20(4):775-783. doi: 10.1111/jch.13239. Epub 2018 Feb 16.
Abstract
Whether elevated uric acid (UA) is an independent risk factor for chronic kidney disease (CKD) is not well established. The authors evaluated the relationship of UA with rapid kidney function decline (RKFD) and incident CKD among 3702 African Americans (AAs) in the Jackson Heart Study with serum UA levels measured at baseline exam (2000-2004). RKFD was defined as ≥ 30% eGFR loss and incident CKD as development of eGFR < 60 mL/min/1.73 m with a ≥ 25% decline in eGFR between baseline and exam 3 (2009-2013). RKFD and CKD were found in 11.4% and 7.5% of the participants, respectively. In a fully adjusted model, the odds of RKFD (OR, 1.8; 95% CI, 1.25-2.49) and incident CKD (OR, 2.00; 95% CI, 1.31-3.06) were significantly higher among participants in the top UA quartile vs bottom quartile. In the JHS, elevated UA was significantly associated with RKFD and incident CKD.
摘要
尿酸（UA）升高是否是慢性肾脏病（CKD）的独立危险因素尚未明确。作者评估了在 Jackson 心脏研究中，3702 名非裔美国人（AA）中尿酸水平在基线检查（2000-2004 年）时测量，UA 与快速肾功能下降（RKFD）和 CKD 发病之间的关系。RKFD 定义为 eGFR 损失≥30%，CKD 为 eGFR <60 ml/min/1.73 m 发展，eGFR 在基线和检查 3（2009-2013 年）之间下降≥25%。参与者中分别有 11.4%和 7.5%发现 RKFD 和 CKD。在完全调整的模型中，UA 最高四分位数组参与者的 RKFD（OR，1.8；95%CI，1.25-2.49）和 CKD 发病（OR，2.00；95%CI，1.31-3.06）的可能性明显高于 UA 最低四分位数组。在 JHS 中，UA 升高与 RKFD 和 CKD 发病显著相关。
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