Guerra Valero Yarmarly C, Wallis Steven C, Lipman Jeffrey, Stove Christophe, Roberts Jason A, Parker Suzanne L
UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia.
Department of Intensive Care Medicine, Royal Brisbane & Women's Hospital, Brisbane, Australia.
Bioanalysis. 2018 Mar;10(6):407-423. doi: 10.4155/bio-2017-0269. Epub 2018 Feb 16.
Conventional sampling techniques for clinical pharmacokinetic studies often require the removal of large blood volumes from patients. This can result in a physiological or emotional burden, particularly for neonates or pediatric patients. Antibiotic pharmacokinetic studies are typically performed on healthy adults or general ward patients. These may not account for alterations to a patient's pathophysiology and can lead to suboptimal treatment. Microsampling offers an important opportunity for clinical pharmacokinetic studies in vulnerable patient populations, where smaller sample volumes can be collected. This systematic review provides a description of currently available microsampling techniques and an overview of studies reporting the quantitation and validation of antibiotics using microsampling. A comparison of microsampling to conventional sampling in clinical studies is included.
临床药代动力学研究的传统采样技术通常需要从患者体内采集大量血液。这可能会给患者带来生理或心理负担，尤其是对于新生儿或儿科患者。抗生素药代动力学研究通常在健康成年人或普通病房患者身上进行。这些研究可能无法考虑患者病理生理学的变化，从而导致治疗效果欠佳。微采样为脆弱患者群体的临床药代动力学研究提供了一个重要机会，因为它可以采集更小的样本量。本系统综述描述了目前可用的微采样技术，并概述了报告使用微采样进行抗生素定量和验证的研究。文中还比较了临床研究中微采样与传统采样的情况。
