Mendes Renato Juvino de Aragão, Pereira Filho Adalberto Alves, Nogueira Aline de Jesus Lustosa, Araújo Karla Regina Freitas, França Clícia Rosane Costa, Carvalho Iramar Borba de, Silva Natale Maria Lindoso da, Azevedo Alexandre Santana, Rosa Ivone Garros
Departamento de Biologia, Centro de Ciências Biológicas e da Saúde, Universidade Federal do Maranhão, São Luís, Maranhão, Brazil.
Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Horizonte, Minas Gerais, Brazil.
Rev Inst Med Trop Sao Paulo. 2018;60:e7. doi: 10.1590/s1678-9946201860007. Epub 2018 Feb 15.
Schistosomiasis is a disease of global extent reaching populations in social vulnerability. One of the control measures of this parasitosis is the use of molluscicidal substances that can fight snails of the genus Biomphalaria, intermediate hosts of Schistosoma mansoni. The aim of this work was to study the toxic activity of three mangrove species (Avicennia schaueriana Stapf. & Leech, ex Moldenke, 1939, Laguncularia racemosa (L.) CF Gaertn, 1807 and Rhizophora mangle L. 1753) on the biological activities of snails Biomphalaria glabrata. Hydroalcoholic extracts were prepared from the stem and leaves of each of the three plant species to which mollusks were exposed. The phytochemical analysis of plants showed the presence of important metabolites in the leaves and stems of L. racemosa and R. mangle, such as tannins and saponins, but the absence of these metabolites in A. schaueriana. Leaf and stem extracts of the three plant species showed low molluscicidal activity, not reaching the standards determined by the World Health Organization (WHO, 1983). L. racemosa and R. mangle has interfered with motility, feeding and oviposition of snails, unlike the extracts of A. schaueriana, which had no effect on these activities.
血吸虫病是一种全球性疾病，影响着社会弱势群体。这种寄生虫病的控制措施之一是使用杀螺物质，以对抗曼氏血吸虫的中间宿主——双脐螺属的蜗牛。本研究的目的是探讨三种红树植物（1939年命名的红海榄、1807年命名的拉贡木和1753年命名的红树）对光滑双脐螺生物活性的毒性作用。从这三种植物的茎和叶中制备水醇提取物，并将蜗牛暴露于提取物中。植物的植物化学分析表明，拉贡木和红树的叶和茎中存在重要的代谢产物，如单宁和皂苷，但红海榄中不存在这些代谢产物。这三种植物的叶和茎提取物显示出较低的杀螺活性，未达到世界卫生组织（1983年）规定的标准。拉贡木和红树提取物干扰了蜗牛的运动、摄食和产卵，而红海榄提取物对这些活动没有影响。
