与大鼠肝脏原位高尔基体形态相比，16,16'-二甲基前列腺素E2（dm PGE2）对链脲佐菌素诱导的富含高尔基体膜部分生化改变的细胞保护作用。
Cytoprotective effect of 16,16' dimethyl prostaglandin E2 (dm PGE2) on streptozotocin-induced biochemical alterations of Golgi-rich membrane fraction in comparison with morphology of rat liver Golgi apparatus in situ.
作者信息
Kordowiak A M
出版信息
Pathol Res Pract. 1986 Aug;181(4):397-401. doi: 10.1016/S0344-0338(86)80074-7.
In 10-11 days after single, intraperitoneal injection of streptozotocin we found a lower (although not statistically significant) yield of Golgi-rich membrane fraction in comparison with control. In these rats similar to control specific activity of galactosyltransferase in nM Gal transferred per h and mg of protein, and statistically significant lower total activity of this enzyme expressed in nM Gal transferred per h and per total liver (t = 2.9666, 0.01 less than p less than 0.05) were found. Organization of Golgi apparatus in situ showed alterations that indicated suppression of secretory activity. Within the dm PGE2 protected animal group the obtained data equal control data.
在单次腹腔注射链脲佐菌素10 - 11天后，我们发现与对照组相比，富含高尔基体的膜组分产量较低（尽管无统计学意义）。在这些大鼠中，每小时每毫克蛋白质转移的半乳糖基转移酶的比活性与对照组相似，且该酶的总活性在每小时每总肝脏转移的纳摩尔半乳糖中具有统计学意义的降低（t = 2.9666，0.01 < p < 0.05）。高尔基体原位组织显示出改变，表明分泌活性受到抑制。在dm PGE2保护的动物组中，获得的数据与对照数据相当。
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