Department of Global and Community Health, College of Health and Human Services, George Mason University, 4400 University Drive MS5B7, Fairfax, VA 22030, USA.
Office of Population Affairs, Office of the Assistant Secretary for Health, Department of Health and Human Services, 1101 Wootton Parkway, Suite 700, Rockville, MD 20852, USA.
Hum Reprod. 2018 Apr 1;33(4):736-744. doi: 10.1093/humrep/dey024.
Is telomere length related to parity among a nationally representative sample of US reproductive age women?
History of live birth was associated with shorter telomere length.
Shorter telomeres have been linked with a range of chronic health conditions and mortality and parity has been associated with health indicators. However, there is a lack of research on how parity relates to telomere length.
STUDY DESIGN, SIZE, DURATION: This nationally representative, cross-sectional study included 1954 women from the National Health and Nutrition Examination Survey, 1999-2002, the only survey period which includes measurement of telomere length.
PARTICIPANTS/MATERIALS, SETTING, METHODS: Women aged 20-44 were included. Parity, defined as number of previous live births, was ascertained by questionnaire. Leukocyte telomere length was measured by polymerase chain reaction and reported as a ratio in relation to standard reference DNA (T/S ratio). The relationship between leukocyte T/S ratio and parity was examined using survey weighted linear regression. Models were adjusted for race/ethnicity, age, BMI, income-to-poverty ratio, education, early age at menarche and smoking status.
Among reproductive age women in the US, the adjusted mean leukocyte T/S ratio was 4.2% (95% CI: 0.9, 7.3) shorter in parous compared with nulliparous women. Parity was associated with 116 fewer base pairs (95% CI: 26, 204) on average, using estimated coefficients from the adjusted linear regression models and mean covariate values.
This study was cross-sectional and therefore was unable to establish temporality. The dataset lacked information on social factors, stress and fertility status, which may help explain these findings. Only two previous studies have examined this question and our findings should be interpreted with caution.
These findings in a nationally representative sample of US reproductive age women suggest that history of live birth may be associated with accelerated cellular aging. The magnitude of the observed association was greater than that of the impact of smoking or obesity on telomere length, suggesting that parity may have an independent influence on cellular aging and warrant further study.
STUDY FUNDING/COMPETING INTEREST(S): The study was funded in part by the Undergraduate Research Scholars Program at George Mason University. The authors have no conflicts of interest.
NA.
在具有全国代表性的美国育龄妇女样本中，端粒长度与生育次数有关吗？
活产史与端粒长度较短有关。
较短的端粒与一系列慢性健康状况和死亡率有关，生育次数与健康指标有关。然而，关于生育次数如何与端粒长度相关的研究还很缺乏。
研究设计、规模、持续时间：这项具有全国代表性的横断面研究包括 1999-2002 年全国健康和营养检查调查中的 1954 名妇女，这是唯一一次包括端粒长度测量的调查。
参与者/材料、地点、方法：纳入年龄在 20-44 岁的妇女。生育次数定义为以前的活产次数，通过问卷调查确定。白细胞端粒长度通过聚合酶链反应测量，并以与标准参考 DNA（T/S 比）的比值报告。使用加权线性回归检验白细胞 T/S 比值与生育次数之间的关系。模型调整了种族/民族、年龄、BMI、收入贫困比、教育程度、初潮年龄和吸烟状况。
在美国育龄妇女中，与未生育的妇女相比，生育的妇女白细胞 T/S 比值平均短 4.2%（95%可信区间：0.9，7.3）。使用调整后的线性回归模型的估计系数和平均协变量值，生育次数平均平均减少 116 个碱基对（95%可信区间：26，204）。
局限性-谨慎原因：本研究为横断面研究，因此无法确定时间顺序。该数据集缺乏社会因素、压力和生育状况的信息，这些信息可能有助于解释这些发现。只有两项先前的研究检查了这个问题，因此我们的发现应谨慎解释。
这些在美国具有全国代表性的育龄妇女样本中的发现表明，活产史可能与细胞加速衰老有关。观察到的关联幅度大于吸烟或肥胖对端粒长度的影响，这表明生育次数可能对细胞衰老有独立影响，值得进一步研究。
研究资金/利益冲突：该研究部分由乔治梅森大学本科生研究学者计划资助。作者没有利益冲突。
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