缺铁患者的红细胞代谢

Red-cell metabolism in patients with iron deficiency.

作者信息

Acharya J, Grimes A J

出版信息

Scand J Haematol. 1986 Jul;37(1):4-9. doi: 10.1111/j.1600-0609.1986.tb01764.x.

DOI:10.1111/j.1600-0609.1986.tb01764.x

Abstract

18 components of metabolism were determined in the red cells of iron-deficient patients and data were expressed per 10(12) red cells to avoid the complicating effects of hypochromia and microcytosis. Glucose consumption, AMP and ATP, glycolytic intermediates except 2,3-bisphosphoglycerate (2,3-DPG) and phosphoenolpyruvate (PEP), red-cell Na+ and the net passive leakage of Na+ and K+ at 4 degrees C were all normal. Creatine, 6-phospho-D-gluconate: NADP oxidoreductase (6PGD) activity and fresh red-cell K+ were raised, suggestive of a young cell population. However, ATP: D-fructose-6-phosphate 1-phosphotransferase (PFK) activity and ADP were low. An elevated 2,3-DPG level was attributable to the anaemia present but the somewhat raised PEP level is unexplained. It is concluded that red cells in iron deficiency show some characteristics of a young cell population; in other respects they appear normal, but in containing a low PFK activity they are abnormal.

摘要

测定了缺铁患者红细胞中18种代谢成分，并以每10¹²个红细胞来表示数据，以避免低色素血症和小红细胞症的复杂影响。葡萄糖消耗、AMP和ATP、除2,3-二磷酸甘油酸（2,3-DPG）和磷酸烯醇丙酮酸（PEP）外的糖酵解中间产物、红细胞Na⁺以及4℃时Na⁺和K⁺的净被动泄漏均正常。肌酸、6-磷酸-D-葡萄糖酸：NADP氧化还原酶（6PGD）活性和新鲜红细胞K⁺升高，提示存在年轻细胞群体。然而，ATP：D-果糖-6-磷酸1-磷酸转移酶（PFK）活性和ADP较低。2,3-DPG水平升高归因于存在的贫血，但PEP水平略有升高的原因尚不清楚。结论是缺铁红细胞表现出一些年轻细胞群体的特征；在其他方面它们看起来正常，但由于含有低PFK活性，它们是异常的。