Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Mol Cell. 2018 Feb 15;69(4):535-536. doi: 10.1016/j.molcel.2018.02.003.
While innate immunity is crucial for host defense, dysregulated signaling activation leads to pathological inflammation. In this issue of Molecular Cell, Goncharov et al. (2018) present a strategy to combat inflammatory diseases by disrupting RIP2-XIAP interaction in NOD2-mediated signaling.
虽然先天免疫对于宿主防御至关重要，但信号转导失调会导致病理性炎症。在本期《分子细胞》中，Goncharov 等人（2018）提出了一种通过破坏 NOD2 介导的信号转导中 RIP2-XIAP 相互作用来治疗炎症性疾病的策略。
