炎症向 RIP2-XIAP 相互作用拮抗剂点头。
Inflammation NODs to Antagonists of RIP2-XIAP Interaction.
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
出版信息
Mol Cell. 2018 Feb 15;69(4):535-536. doi: 10.1016/j.molcel.2018.02.003.
Abstract
While innate immunity is crucial for host defense, dysregulated signaling activation leads to pathological inflammation. In this issue of Molecular Cell, Goncharov et al. (2018) present a strategy to combat inflammatory diseases by disrupting RIP2-XIAP interaction in NOD2-mediated signaling.
摘要
虽然先天免疫对于宿主防御至关重要，但信号转导失调会导致病理性炎症。在本期《分子细胞》中，Goncharov 等人（2018）提出了一种通过破坏 NOD2 介导的信号转导中 RIP2-XIAP 相互作用来治疗炎症性疾病的策略。
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本文引用的文献
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2
Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.RIP2激酶的非活性和活性状态结构揭示了激活机制。
PLoS One. 2017 May 18;12(5):e0177161. doi: 10.1371/journal.pone.0177161. eCollection 2017.
3
The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.泛素连接酶 XIAP 招募 LUBAC 参与 NOD2 信号转导，在炎症和先天免疫中发挥作用。
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J Biol Chem. 2012 Jun 29;287(27):23057-67. doi: 10.1074/jbc.M112.344283. Epub 2012 May 1.
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