未开发的储备：控制原始卵泡生长激活。
Untapped Reserves: Controlling Primordial Follicle Growth Activation.
机构信息
Yale University School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Reproductive Endocrinology, New Haven, CT, USA.
University of Colorado Anschutz Medical Campus, Department of Obstetrics and Gynecology, Divisions of Reproductive Endocrinology and Infertility and Reproductive Sciences, Aurora, CO 80045, USA.
出版信息
Trends Mol Med. 2018 Mar;24(3):319-331. doi: 10.1016/j.molmed.2018.01.008. Epub 2018 Feb 13.
Abstract
Even with the benefit of assisted reproductive technologies (ART), many women are unable to conceive and deliver healthy offspring. One common cause of infertility is the inability to produce eggs capable of contributing to live birth. This can occur despite standard-of-care treatment to maximize the recovery of eggs from growing ovarian follicles. Dormant primordial follicles in the human ovary are a 'reserve ' that can be exploited clinically to overcome this problem. We discuss how controlling primordial follicle growth activation (PFGA) can produce increased numbers of high-quality eggs available for fertility treatment(s). We consider the state of the art in interventions used to control PFGA, and consider genetic and epigenetic strategies on the horizon that might improve compromised oocyte quality to increase live births.
摘要
即使有辅助生殖技术（ART）的帮助，许多女性仍然无法怀孕并生育健康的后代。不孕的一个常见原因是无法产生能够有助于活产的卵子。尽管进行了标准的护理治疗以最大程度地从生长的卵巢卵泡中回收卵子，但这种情况仍会发生。人类卵巢中的休眠原始卵泡是一种“储备”，可以通过临床利用来克服这个问题。我们讨论了如何控制原始卵泡生长激活（PFGA）以产生更多可用于生育治疗的高质量卵子。我们考虑了用于控制 PFGA 的现有干预措施的状态，并考虑了可能改善受损卵母细胞质量以增加活产的潜在遗传和表观遗传策略。
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