Maksimov N A, Varshavskiĭ V A, Balkarov I M, Pal'tsev M A, Poliantseva L R
Ter Arkh. 1986;58(8):97-101.
The authors described the results of an immunohistochemical, electron microscopic and morphometric study of the kidney bioptates of 45 patients with latent glomerulonephritis with hyperuricemia, 8 patients with primary gout and 12 patients with latent glomerulonephritis without hyperuricemia. Two possible variants of the involvement of the renal glomerula were revealed against a background of purine metabolism: typical immunocomplex glomerulonephritis and the so called "reactive" mesangial changes. The expression of interstitial changes (by the results of histometric investigation) was maximum in gout, slightly less in latent nephritis with hyperuricemia and minimum in nephritis without hyperuricemia. The authors emphasized the possibility of immunocomplex nephritis as one of the variants of renal lesion in gout and hyperuricemia and the necessity of specifying therapeutic modalities to be used in this condition including general nephrological approaches to the treatment of latent nephropathies.
作者描述了对45例伴有高尿酸血症的隐匿性肾小球肾炎患者、8例原发性痛风患者和12例无高尿酸血症的隐匿性肾小球肾炎患者的肾脏活检组织进行免疫组织化学、电子显微镜和形态计量学研究的结果。在嘌呤代谢背景下，发现肾小球受累有两种可能的类型：典型的免疫复合物性肾小球肾炎和所谓的“反应性”系膜改变。（根据组织测量学研究结果）间质改变的表达在痛风中最为明显，在伴有高尿酸血症的隐匿性肾炎中略低，在无高尿酸血症的肾炎中最低。作者强调免疫复合物性肾炎作为痛风和高尿酸血症中肾脏病变的一种类型的可能性，以及明确在这种情况下使用的治疗方式的必要性，包括对隐匿性肾病进行治疗的一般肾脏病学方法。
