The Department of Psychology, The University of York, Heslington, York, North Yorkshire, YO10 5DD, UK.
Cognitive Neuroscience Unit, Faculty of Health, Deakin University Burwood Campus, 221 Burwood Highway, Melbourne, VIC, 3125, Australia.
J Autism Dev Disord. 2018 Jul;48(7):2350-2367. doi: 10.1007/s10803-018-3492-2.
ASD is associated with mentalizing deficits that may correspond with atypical mirror system (MS) activation. We investigated MS activity in adults with and without ASD when inferring others' intentions using TMS-induced motor evoked potentials (MEPs) and mu suppression measured by EEG. Autistic traits were measured for all participants. Our EEG data show, high levels of autistic traits predicted reduced right mu (8-10 Hz) suppression when mentalizing. Higher left mu (8-10 Hz) suppression was associated with superior mentalizing performances. Eye-tracking and TMS data showed no differences associated with autistic traits. Our data suggest ASD is associated with reduced right MS activity when mentalizing, TMS-induced MEPs and mu suppression measure different aspects of MS functioning and the MS is directly involved in inferring intentions.
ASD 与心理化缺陷有关，这种缺陷可能与异常的镜像系统 (MS) 激活相对应。我们通过 TMS 诱导的运动诱发电位 (MEP) 和 EEG 测量的 mu 抑制，研究了 ASD 患者和非 ASD 患者在推断他人意图时的 MS 活动。我们还为所有参与者测量了自闭症特征。我们的 EEG 数据显示，高水平的自闭症特征预示着在进行心理化时，右侧 mu（8-10 Hz）抑制减少。较高的左侧 mu（8-10 Hz）抑制与更好的心理化表现相关。眼动追踪和 TMS 数据没有显示出与自闭症特征相关的差异。我们的数据表明，ASD 在进行心理化时与右侧 MS 活动减少有关，TMS 诱导的 MEP 和 mu 抑制测量了 MS 功能的不同方面，MS 直接参与了意图推断。
